Novel Deleterious nsSNPs within MEFV Gene that Could Be Used as Diagnostic Markers to Predict Hereditary Familial Mediterranean Fever: Using Bioinformatics Analysis

Table 3

Stability analysis predicted by I-Mutant version 3.0 (also show the 23 novel mutations).

Amino Acid Change	SVM2 Prediction Effect	RI	DDG Value Prediction
S749Y	Decrease	0	-0.2
F743S	Decrease	6	-1.16
Y741C	Decrease	8	-2.5
F731V	Decrease	6	-1.52
I720T	Decrease	4	-0.92
L709R	Decrease	3	-0.56
V691G	Decrease	7	-1.25
W689R	Decrease	7	-0.73
G668R	Decrease	4	-0.37
V659F	Decrease	2	-0.19
F636C	Decrease	8	-1.28
R461W	Increase	1	-0.01
H407Q	Decrease	8	-1.48
H407R	Decrease	5	-1.1
H404R	Decrease	1	-0.06
C398Y	Decrease	2	-0.09
C395Y	Increase	4	0.26
C395F	Increase	1	0.04
C395R	Increase	4	0.13
H378Q	Decrease	4	-0.68
H378Y	Decrease	3	-0.26
C375R	Increase	2	-0.01
L86P	Decrease	2	-0.56