Table 4: The MEFV gene functions and its appearance in network and genome.

FunctionFDRGenes in networkGenes in genome

nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway1.42E-07647
regulation of interleukin-1 beta production0.000129426
interleukin-1 beta production0.000129430
regulation of interleukin-1 production0.000129430
interleukin-1 production0.000196435
intracellular receptor signaling pathway0.0002016207
positive regulation of cysteine-type endopeptidase activity0.0104384101
positive regulation of endopeptidase activity0.0106634105
positive regulation of peptidase activity0.0114109
inflammatory response0.0182465283
regulation of chemokine production0.018246339
chemokine production0.022338344
regulation of cysteine-type endopeptidase activity0.0332384160
tumor necrosis factor production0.033238354
regulation of tumor necrosis factor production0.033238354
tumor necrosis factor superfamily cytokine production0.0407359
regulation of I-kappaB kinase/NF-kappaB signaling0.0469024185
I-kappaB kinase/NF-kappaB signaling0.0577224198
positive regulation of cytokine production0.0650044207
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process0.099763393
positive regulation of interleukin-1 beta secretion0.099763215
defense response to Gram-negative bacterium0.099763216
cysteine-type endopeptidase activator activity involved in apoptotic process0.099763217
regulation of endopeptidase activity0.0997634251
glycosaminoglycan binding0.099763388
regulation of extrinsic apoptotic signaling pathway0.099763392
regulation of peptidase activity0.0997634258
positive regulation of interleukin-1 secretion0.099763216
regulation of interleukin-1 beta secretion0.099763217

FDR: false discovery rate is greater than or equal to the probability that this is a false positive.