Novel Deleterious nsSNPs within MEFV Gene that Could Be Used as Diagnostic Markers to Predict Hereditary Familial Mediterranean Fever: Using Bioinformatics Analysis

Table 4

The MEFV gene functions and its appearance in network and genome.

Function	FDR	Genes in network	Genes in genome
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	1.42E-07	6	47
regulation of interleukin-1 beta production	0.000129	4	26
interleukin-1 beta production	0.000129	4	30
regulation of interleukin-1 production	0.000129	4	30
interleukin-1 production	0.000196	4	35
intracellular receptor signaling pathway	0.000201	6	207
positive regulation of cysteine-type endopeptidase activity	0.010438	4	101
positive regulation of endopeptidase activity	0.010663	4	105
positive regulation of peptidase activity	0.011	4	109
inflammatory response	0.018246	5	283
regulation of chemokine production	0.018246	3	39
chemokine production	0.022338	3	44
regulation of cysteine-type endopeptidase activity	0.033238	4	160
tumor necrosis factor production	0.033238	3	54
regulation of tumor necrosis factor production	0.033238	3	54
tumor necrosis factor superfamily cytokine production	0.0407	3	59
regulation of I-kappaB kinase/NF-kappaB signaling	0.046902	4	185
I-kappaB kinase/NF-kappaB signaling	0.057722	4	198
positive regulation of cytokine production	0.065004	4	207
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	0.099763	3	93
positive regulation of interleukin-1 beta secretion	0.099763	2	15
defense response to Gram-negative bacterium	0.099763	2	16
cysteine-type endopeptidase activator activity involved in apoptotic process	0.099763	2	17
regulation of endopeptidase activity	0.099763	4	251
glycosaminoglycan binding	0.099763	3	88
regulation of extrinsic apoptotic signaling pathway	0.099763	3	92
regulation of peptidase activity	0.099763	4	258
positive regulation of interleukin-1 secretion	0.099763	2	16
regulation of interleukin-1 beta secretion	0.099763	2	17

FDR: false discovery rate is greater than or equal to the probability that this is a false positive.