Table 2: Piper ranking of docked complex based on cluster size, where peptides with () represent the experimentally validated against MERS-CoV and are considered as positive controls.

Rank Peptide Length DefinitionSpecies Cluster

1 P930 Mouse Beta-defensin Mouse 328
2 AP0022531RatNP-4 (rat defensin) Rat 285
3 AP0018032Human defensin 5 (alpha defensin) Human277
4 AP0054940Plectasin (fungal defensin) Fungus 270
5 AP0074441AvBD-5, chicken avian beta defensin) Chicken253
6 AP0072929Kalata B1 (cyclotides) Plant 247
7 AP0076424Dermaseptin-S9 Frog 223
8 AP0022332RatNP-2 (rat alpha defensin) Rat 219
9 HR2P36 HR2 region of MERS-CoV Synthetic 208

10 AP0016028Dermaseptin-S4 Frog 200
11 AP0017431Guinea pig neutrophil cationic peptide 1 Guinea pig193
12 AP0073031Kalata B8 (cyclotides) Plant 175
13 AP0022232RatNP-1 (rat alpha defensin,) Rat 175
14 AP0266323Piscidins Fish 171
15 AP0106131Circulin D (cyclotides) Plant 163
16 AP0135646Cp-thionin II Plant 160
17 AP0053220Lunatusin Plant 157
18 AP0257131Cycloviolacin VY1 (cyclotides) Plant 155
19 AP0069230HFIAP-3 (Hagfish cathelicidin) Fish148
20 AP0026022Maculatin 1.1 Frog 146
21 AP0273355Piscidin Fish 144
22 AP0027531Circulin B (cyclotides) Plant 143
23 AP0164430Brevinin-2-RN1 Frog 143
24 AP0214850Apl-AvBD16 (Beta def) Bird 139
25 AP0106531Cycloviolacin 014 (cyclotides) Plant 136
26 AP0102231Cycloviolin A (cyclotides) Plant 134
27 AP0003638Bovine Beta-defensin 1 Bovine 127
28 AP0007424Brevinin-1 Frog 120
29 AP0034025Chrysophsin-2 Fish 120
30 AP0016625Pleurocidin Fish 118
31 AP0283043ccBD (Channel Catfish beta def) Fish 115
32 AP0018132Human defensin 6 Human 115
33 AP0178843Myticin C molluscs 111
34 AP0017933Human neutrophil peptide-4 (Alpha def) Human97
35 AP0064133Pardaxin 1 Fish 96
36 AP0077123Magainin 1 Frog 90
37 AP0074242Chicken AvBD6 (Beta def) Chicken 88
38 AP0014423Magainin 2 Frog 85
39 AP0084643Mundticin KS (Bacteriocin) Bacteria66