Table 4: ClusPro ranking of docked complex based on energy scores, where peptides with () represent the experimentally validated against MERS-CoV and are considered as positive controls.

Rank Peptide Length DefinitionSpecies Representative Energy

1 AP0026022Maculatin 1.1 Frog Center -1692.0
2 AP0273355Piscidin Fish Center -1581.2
3 AP0017933Human neutrophil peptide-4 (Alpha def) Human Center -1498.5
4 AP0034025Chrysophsin-2 Fish Center -1488.6
5 AP0018132Human defensin 6 Human Center -1399.5
6 AP0018032Human defensin 5 (alpha defensin) Human Center -1340.8
7 AP0022232RatNP-1 (rat alpha defensin,) Rat Center -1340.8
8 AP0022332RatNP-2 (rat alpha defensin) Rat Center -1340.8
9 AP0076424Dermaseptin-S9 Frog Center -1338.8
10 AP0074242Chicken AvBD6 (Beta def) Chicken Center -1264.8
11 AP0214850Apl-AvBD16 (Beta def) Bird Center -1264.8
12 HR2P36HR2 region of MERS-CoV Synthetic Center -1256.9
13 AP0017431Guinea pig neutrophil cationic peptide 1 Guinea pig Center -1223.0
14 AP0178843Myticin C molluscs Center -1202.7
15 AP0283043ccBD (Channel Catfish beta def) Fish Center -1184.3
16 AP0007424Brevinin-1 Frog Center -1184.2
17 AP0266323Piscidins Fish Center -1184.2
18 AP0135646Cp-thionin II Plant Center -1139.1
19 AP0016625Pleurocidin Fish Center -1137.1
20 AP0022531RatNP-4 (rat defensin) Rat Center -1103.8
21 AP0003638Bovine Beta-defensin 1 Bovine Center -1103.7
22 AP0074441AvBD-5, chicken avian beta defensin) Chicken Center -1103.7
23 AP0016028Dermaseptin-S4 Frog Center -1097.0
24 AP0064133Pardaxin 1 Fish Center -1050.1
25 AP0054940Plectasin (fungal defensin) Fungus Center -994.2
26 AP0027531Circulin B (cyclotides) Plant Center -993.9
27 AP0102231Cycloviolin A (cyclotides) Plant Center -993.9
28 AP0106131Circulin D (cyclotides) Plant Center -993.9
29 AP0084643Mundticin KS (Bacteriocin) Bacteria Center -937.1
30 P930Mouse Beta-defensin Mouse Center -925.5
31 AP0053220Lunatusin Plant Center -921.9
32 AP0257131Cycloviolacin VY1 (cyclotides) Plant Center -897.7
33 AP0014423Magainin 2 Frog Center -868.2
34 AP0077123Magainin 1 Frog Center -868.2
35 AP0164430Brevinin-2-RN1 Frog Center -868.2
36 AP0069230HFIAP-3 (Hagfish cathelicidin) Fish Center -821.3
37 AP0072929Kalata B1 (cyclotides) Plant Center -805.8
38 AP0073031Kalata B8 (cyclotides) Plant Center -805.8
39 AP0106531Cycloviolacin 014 (cyclotides) Plant Center -805.8