Table 5: Binding mode of each peptide-protein complex using Protein Interaction Calculator (PIC) server.

APD3 IDHydrophobic interactions Main chain Hydrogen bond interactions Side chain Hydrogen bond interactions Ionic interactions Aromatic-aromatic interactions Aromatic-sulphur interactions

P9Tyr64, Ile69, Tyr809, Ala920, Tyr928, Val929, Tyr932, Ala1037Asn812, Ser919, Asp922, Asn1042, Asn812, Ser1038Tyr932Glu1039Tyr928, Tyr64 Cys925

AP00549 Ala1049, Pro59, Tyr64, Tyr928, Val929, Ala930, Ala920, Ile69, Tyr71Ala1049, Gly61Gln60, Gln1056, Cys925 Arg1057, Arg62, Asp922Tyr928, Tyr71 -

AP00225Val790, Tyr1142, Phe764, Leu731, Ile768, Pro1143, Pro767, Val770 Pro730 Thr791, Gln1119, Tyr1141, Leu729, Asn765, Leu731, His1146, Asn765, His766 Gln792, Ser734Glu1017Tyr1142

AP00180 Ala1007, Val790, Leu731, Pro767, Ile768, Tyr1142 Gly789, Pro730 Gln1119, Tyr1142, Leu731, Leu729, Pro730, Asn765 Aln1007Glu1017, Asp740 - Cys1142

AP00744 Leu1200, Pro767, Val1168, Ile1180, Leu780, Phe778, Pro1143, Val983, Ile985 Ala1206 Cys1164, Val770, Tyr1153, Ser781 Asp771Tyr1142 -

HR2P Tyr1153, Ile1165, Val1168, Ile1180, Val1181, Leu780, Val770, Pro767, Pro1143, Tyr1142, Val790, Leu729, Pro730, Leu731-Asn1169His1146, His766- -