Synthesis and Antimicrobial Studies of Pyrimidine Pyrazole Heterocycles

Table 1

Structure, formula, and yields of compounds 5a–l.

Entry	R	X	Ar	Chalcone (4a–l)	Cyclised product (5a–l)	Yield (%)
2a, 3a, 4a, 5a	–CH3	O	p-CH3			66
2a, 3b, 4b, 5b	–CH3	O	p-OCH3			66
2a, 3c, 4c, 5c	–CH3	O	p-Br			80
2a, 3d, 4d, 5d	–CH3	O	p-Cl			66
2b, 3a, 4e, 5e	C6H6	S	p-CH3			64
2b, 3b, 4f, 5f	C6H6	S	p-OCH3			80
2b, 3c, 4g, 5g	C6H6	S	p-Br			46
2b, 3d, 4h, 5h	C6H6	S	p-Cl			78
2c, 3a, 4i, 5i	o-OCH3C6H5	S	p-CH3			68
2c, 3b, 4j, 5j	o-OCH3C6H5	S	p-OCH3			68
2c, 3c, 4k, 5k	o-OCH3C6H5	S	p-Br			80
2c, 3d, 4l, 5l	o-OCH3C6H5	S	p-Cl			81