Research Article
Synthesis and Antimicrobial Studies of Pyrimidine Pyrazole Heterocycles
Table 2
Antifungal activity of pyrimidine pyrazole analogues.
| | Compound | MIC | | DDA (μg/disc) | MDA (μg/mL) | PSGI (μg/mL) | | A. flavus | A. niger | A. fumigatus | A. flavus | A. niger | A. fumigatus | A. flavus | A. niger | A. fumigatus |
| | 5c | 46.75 | 46.75 | 46.75 | 500 | 500 | 250 | 500 | 500 | 250 | | 5e | — | — | — | — | — | — | — | — | — | | 5f | — | — | — | — | — | — | — | — | — | | 5g | — | — | — | — | — | — | — | — | — | | 5h | — | — | — | — | — | — | — | — | — | | 5i | — | — | — | — | — | — | — | — | — | | 5j | 187.5 | 187.5 | 46.75 | 500 | 1000 | 500 | 500 | 1000 | 500 | | 5k | — | — | — | — | — | — | — | — | — | | 5l | — | — | — | — | — | — | — | — | — |
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—: no significant inhibition.
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