Synthesis and Antimicrobial Studies of Pyrimidine Pyrazole Heterocycles

Table 3

In vitro combination of compound 5c with polyene (AmpB, NYS) against A. fumigatus.

Strain	MIC (µg/mL)					FIC index		Interpretation
	5c	AmpB	NYS	AmpB + 5c	NYS + 5c	AmpB + 5c	NYS + 5c	AmpB + 5c	NYS + 5c
ITCC 4517	250	1.95	3.9	1.56/6.25	3.12/12.50	0.83 (0.8 + 0.03)	0.85 (0.8 + 0.05)	IND	IND
ITCC 1634	500	1.95	3.9	3.12/12.50	3.12/12.50	1.62 (1.6 + 0.02)	0.83 (0.8 + 0.03)	IND	IND
VPCI 190/96	250	1.95	3.9	1.56/6.25	3.12/12.50	0.83 (0.8 + 0.03)	0.85 (0.8 + 0.05)	IND	IND
Geometric mean	314.98	1.95	3.9	1.96/7.87	3.12/12.50	1.03 (1.00 + 0.3)	0.83 (0.8 + 0.03)	IND	IND

IND: indifference.