Synthesis and Antimicrobial Studies of Pyrimidine Pyrazole Heterocycles

Table 4

In vitro combination of compound 5c with azole (KTZ, FLZ) against A. fumigatus.

Strain	MIC (µg/mL)					FIC index		Interpretation
	5c	KTZ	FLZ	KTZ + 5c	FLZ + 5c	KTZ + 5c	FLZ + 5c	KTZ + 5c	FLZ + 5c
ITCC 4517	250	31.25	500	6.25/50.0	50.0/200.0	0.40 (0.2 + 0.2)	0.9 (0.1 + 0.8)	SYN	IND
ITCC 1634	500	62.50	250	25.0/100.0	100.0/400.0	0.60 (0.4 + 0.2)	1.2 (0.4 + 0.8)	IND	IND
VPCI 190/96	250	31.25	250	12.50/50.0	50.0/200.0	0.60 (0.4 + 0.2)	1.0 (0.2 + 0.8)	IND	IND
Geometric mean	314.98	39.37	314.98	7.87/62.9	62.9/251.98	0.52 (0.32 + 0.20)	1.0 (0.2 + 0.8)	IND	IND

IND: indifference; SYN: synergy.