Research Article
Synthesis and Antimicrobial Studies of Pyrimidine Pyrazole Heterocycles
Table 6
In vitro combination of compound 5j with azole (KTZ and FLZ) against A. fumigatus.
| | Strain | MIC (µg/mL) | FIC index | Interpretation | | 5j | KTZ | FLZ | KTZ + 5j | FLZ + 5j | KTZ + 5j | FLZ + 5j | KTZ + 5j | FLZ + 5j |
| | ITCC 4517 | 250.00 | 31.25 | 500.00 | 25.00/100.00 | 50.00/200.00 | 1.20 (0.8 + 0.4) | 0.90 (0.1 + 0.8) | IND | IND | | ITCC 1634 | 500.00 | 62.50 | 250.00 | 25.00/100.00 | 100.00/400.00 | 0.60 (0.4 + 0.2) | 1.20 (0.4 + 0.8) | IND | IND | | VPCI 190/96 | 500.00 | 31.25 | 250.00 | 25.0/100.00 | 50.00/200.00 | 0.50 (0.4 + 0.1) | 0.60 (0.2 + 0.4) | SYN | IND |
| | Geometric mean | 396.85 | 39.37 | 314.90 | 25.00/100.00 | 62.99/251.98 | 0.7 (0.5 + 0.2) | 0.83 (0.2 + 0.63) | IND | IND |
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IND: indifference.
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