Table of Contents
Advances in Chemistry
Volume 2014, Article ID 589686, 20 pages
Review Article

The Biological Side of Water-Soluble Arene Ruthenium Assemblies

1Institut de Chimie, Université de Neuchâtel, Avenue de Bellevaux 51, 2000 Neuchâtel, Switzerland
2Departement für Chemie und Biochemie, Universität Bern, Freiestraße 3, 3012 Berne, Switzerland

Received 4 March 2014; Accepted 23 April 2014; Published 17 July 2014

Academic Editor: Fazlul Haq

Copyright © 2014 Bruno Therrien and Julien Furrer. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This review article covers the synthetic strategies, structural aspects, and host-guest properties of ruthenium metalla-assemblies, with a special focus on their use as drug delivery vectors. The two-dimensional metalla-rectangles show interesting host-guest possibilities but seem less appropriate for being used as drug carriers. On the other hand, metalla-prisms allow encapsulation and possible targeted release of bioactive molecules and consequently show some potential as drug delivery vectors. The reactivity of these metalla-prisms can be fine-tuned to allow a fine control of the guest’s release. The larger metalla-cubes can be used to stabilize the formation of G-quadruplex DNA and can be used to encapsulate and release photoactive molecules such as porphins. These metalla-assemblies demonstrate great prospective in photodynamic therapy.