A Conformational Model for MTPA Esters of Chiral N-(2-Hydroxyalkyl)acrylamides
Figure 3
(a) Newman projections along the axes C1–C2 (up) and C1′–C2′ (down) for the most stable conformer of (R)-3b. Torsion angles Tor1 and Tor2 are indicated. Major contributions to this type of conformation are highlighted in the energy level diagram on the right. (b) Picture of a 3D molecular render of the same conformer showing intramolecular hydrogen bonding between amide hydrogen and a fluorine atom (H–F distance: 2.3 angstrom).
