Research Article
In Silico Molecular Docking Analysis of Natural Pyridoacridines as Anticancer Agents
Table 4
Number of sites estimated via e-pharmacophores generation for different PCNPs against selected cancer macromolecules.
| | S. Number | Pyridoacridine analogues (cancer macromolecule) | Number of sites |
| | 1 | Meridine (CDK-6) | 6 | | 2 | Meridine (IGF-1R kinase) | 5 | | 3 | Meridine (CDK-2) | 6 | | 4 | Meridine (Bcl-2) | 3 | | 5 | Meridine (G-Quadruplex) | 4 | | 6 | Deoxyamphimedine (CDK-2) | 5 | | 7 | Deoxyamphimedine (CDK-6) | 5 | | 8 | Deoxyamphimedine (Bcl-2) | 4 | | 9 | Deoxyamphimedine (IGF-1R kinase) | 3 | | 10 | Deoxyamphimedine (G-Quadruplex) | 3 | | 11 | Neoamphimedine (CDK-6) | 5 | | 12 | Neoamphimedine (IGF-1R kinase) | 4 | | 13 | Neoamphimedine (VEGFR-2) | 1 | | 14 | Neoamphimedine (G-Quadruplex) | 3 | | 15 | Neoamphimedine (CDK-2) | 4 | | 16 | Neoamphimedine (Bcl-2) | 5 | | 17 | Amphimedine (Bcl-2) | 4 | | 18 | Amphimedine (G-Quadruplex) | 3 | | 19 | Amphimedine (CDK-6) | 5 | | 20 | Amphimedine (VEGFR-2) | 8 | | 21 | Amphimedine (CDK-2) | 5 | | 22 | Amphimedine (IGF-1R kinase) | 4 | | 23 | Varamine A (CDK-2) | 4 | | 24 | Varamine A (IGF-1R kinase) | 4 | | 25 | Varamine A (Bcl-2) | 6 | | 26 | Varamine A (CDK-6) | 5 | | 27 | Varamine A (G-Quadruplex) | 4 |
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