Identification and Structural Characterization of Unidentified Impurity in Bisoprolol Film-Coated Tablets

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Endpoint specific profilers</td><td class="align_center" colspan="2">Structural alerts</td></tr><tr class="thead"><td class="align_center">Bisoprolol API</td><td class="align_center">Impurity RRT 0.95</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">Carcinogenicity (genotoxic and nongenotoxic) by ISS</td><td class="align_center">No alert found</td><td class="align_center">No alert found</td></tr><tr><td class="align_left">DNA alerts for Ames by OASIS</td><td class="align_center">No alert found</td><td class="align_center">No alert found</td></tr><tr><td class="align_left">DNA alerts for CA and MNT by OASIS</td><td class="align_center">No alert found</td><td class="align_center">No alert found</td></tr><tr><td class="align_left">In vitro mutagenicity (Ames test) by ISS</td><td class="align_center">No alert found</td><td class="align_center">No alert found</td></tr><tr><td class="align_left">In vivo chromosomal mutation</td><td class="align_center">H-acceptor-path3-H-acceptor</td><td class="align_center">H-acceptor-path3-H-acceptor</td></tr><tr><td class="align_left">OncoLogic primary classification</td><td class="align_center">No alert found</td><td class="align_center">No alert found</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

QSAR Toolbox profiling of Bisoprolol API and Impurity RRT 0.95.

Advances in Chemistry

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Table 5

Table 5: Identification and Structural Characterization of Unidentified Impurity in Bisoprolol Film-Coated Tablets 