QSAR Study of Anthra[1,9-cd]pyrazol-6(2H)-one Derivatives as Potential Anticancer Agents Using Statistical Methods

Table 1

Studied compounds and radicals.

	Compounds	R1	PIC50
	1	Cl	1,258
	2	NHCH2CH(CH3)2	1,251
	3	NHCH2CH2CH3	1,491
	4	NHCH2CH2CH2CH2CH2OH	1.000
	5	NHCH2CH2C6H5	1,340
	6	NH-Cyclohexane	1,109
	7	NH-Cyclopentane	1,200
	8	NHCH2-Cyclohexane	1,302
	9	NHCH2CH2CH2OH	1,160
	10	NHCH2CH2CH2CH3	1,386
	11	NH CH3	1,556
	12	NHCH2C6H5	0,946
	13	NHCH2CH2-Cyclohexane	1,505
	14		1,532
	15		0,926
	16		0,740
	17	Cl	1,137
	18	NHCH2CH(CH3)2	1,455
	19	NHCH2CH2CH3	1,484
	20	NHCH2CH2CH2CH2CH2OH	1,486
	21	NHCH2CH2C6H5	1,489
	22	NH-Cyclohexane	1,490
	23	NH-Cyclopentane	1,346
	24	NHCH2-Cyclohexane	1,254
	25	NHCH2CH2CH2OH	1,272
	26	NHCH2CH2CH2CH3	1,519
	27	NH CH3	1,487
	28	NHCH2C6H5	1,493
	29	NHCH2CH2-Cyclohexane	1,324
	30		1,505
	31		1,504
	32		1,497