Genomic Designs of rAAVs Contribute to Pathological Changes in the Livers and Spleens of Mice

Figure 2

Echogenicity measurement of all C57BL/6 mice injected with AAV. (a) Representative day 90 and day 194 liver ultrasound images for all groups of C57BL/6 mice. Arrows indicate Portal Triad features on D90 images: blue: portal vein; red: hepatic artery; and green: bile duct. (b, c) Whole-liver echogenicity analysis via average pixels of liver images. (d, e) Echogenicity analysis of a region of interest near the Portal Triad. ANOVA value significant for (b) only. values for (c–e) are 0.1705, 0.0658, and 0.4697. for all groups except CB-PolyA ().

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