Genomic Designs of rAAVs Contribute to Pathological Changes in the Livers and Spleens of Mice

Figure 4

Histology of livers reveals alterations in collagenous area of AAV-injected C57s. (a) Representative 10x images of collagenous area in C57 livers. (b) Collagen area low in livers of TTR-hFIX, and high in CB-PolyA and CB-hFIX-injected mice. Kruskal-Wallis test performed. (c) H&E 20x images of C57 livers. Cytoplasmic clearing and EMH detected in several mice. for CB-PolyA, for all other groups.

(a)

(b)

(c)