Is Dopamine an Iatrogenic Disruptor of Thyroid and Cortisol Function in the Extremely Premature Infant?
Table 1
Comparison of infants exposed to dopamine and infants not exposed to dopamine treatment.
Dopamine exposure (D+)
No dopamine (D−)
Difference (95% CI D+ minus D−)
value
Gender (males)
21.0 (60%)
22 (51%)
0.09 (−0.26, 0.54)
Gestation (weeks)
−1.44 (−1.93, −0.93)
<0.001
24.54 (1.27)
25.98 (0.98)
Maternal steroids
0.08 (−0.68, 2.65)
33.0 (94%)
37.0 (86%)
Maternal age
−6.19 (−16.62, 4.24)
0.241
27.97 (4.42)
30.16 (30.47)
Lowest mean arterial pressure
−4.77 (−7.01, −2.49)
<0.001
22.0 (4.92)
26.75 (3.87)
Highest blood lactate in the first 12 hours
0.34 (−1.11, 1.80)
0.121
6.44 (3.32)
6.10 (2.74)
CRIB score
3.51 (1.92, 5.10)
<0.001
7.25 (4.03)
3.74 (2.67)
FT4 (pmol/L)
−7.19 (−9.81, −4.58)
<0.001
6.48 (4.01)
13.61 (5.01)
TSH (mU/L)
−0.78 (−1.92, 0.36)
0.177#
Median 2.21
Median 2.98
IQR (1.1, 3.4)
IQR (2.32)
TT4 (nmol/L)
−33.68 (−51.49, −15.86)
0.018
46.22 (33.60)
79.90 (32.87)
TT3 (nmol/L)
−0.38 (−0.58, −0.18)
0.012
0.40 (0.22)
0.77 (0.35)
Cortisol (nmol/L)
219.26
0.380
521.67 (454.80)
480.40 (192.50)
(54.44, 384.08)
Data expressed as mean (SD) for continuous parametric outcomes, Student’s -test; (%) for categorical outcomes, chi-square, median, and interquartile ranges (IQR) for nonparametric outcomes; Mann-Whitney and difference in medians calculated using Hodges-Lehmann estimate and Moses distribution free 95% confidence interval.