Table of Contents
Advances in Endocrinology
Volume 2015, Article ID 254042, 8 pages
http://dx.doi.org/10.1155/2015/254042
Review Article

Cystatin C and Its Role in Patients with Type 1 and Type 2 Diabetes Mellitus

1Endocrine Division, Dubai Hospital, P.O. Box 7272, Dubai, UAE
2Nephrology Department, Faculty of Medicine, Ain Shams University, P.O. Box 7047-112, Cairo, Egypt
3Nephrology Division, Dubai Hospital, Dubai Health Authority, Dubai, UAE
4Diabetology Unit, Rashid Hospital, P.O. Box 4545, Dubai, UAE

Received 12 July 2014; Revised 14 October 2014; Accepted 20 October 2014

Academic Editor: Tomohito Gohda

Copyright © 2015 Alaaeldin M. Bashier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Ritz and S. R. Orth, “Nephropathy in patients with type 2 diabetes mellitus,” The New England Journal of Medicine, vol. 341, no. 15, pp. 1127–1133, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. US Renal Data System, USRDS 2003 Annual Data Report: Atlas of End-Stage Renal Disease in the United States, National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md, USA, 2003.
  3. B. A. Young, C. Maynard, and E. J. Boyko, “Racial differences in diabetic nephropathy, cardiovascular disease, and mortality in a national population of veterans,” Diabetes Care, vol. 26, no. 8, pp. 2392–2399, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. I. H. de Boer, T. C. Rue, P. A. Cleary et al., “Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the diabetes control and complications trial/epidemiology of diabetes interventions and complications cohort,” Archives of Internal Medicine, vol. 171, no. 5, pp. 412–420, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. “KDIGO 2012 clinical practice guideline for evaluation and management of chronic kidney disease,” Kidney International Supplements, vol. 3, no. 1, pp. 1–150, 2013.
  6. A. I. Adler, R. J. Stevens, S. E. Manley, R. W. Bilous, C. A. Cull, and R. R. Holman, “Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64),” Kidney International, vol. 63, no. 1, pp. 225–232, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. “American Diabetes Association: nephropathy in diabetes (Position Statement),” Diabetes Care, vol. 27, supplement 1, pp. S79–S83, 2004.
  8. J. M. Stephenson and J. H. Fuller, “Microalbuminuria is not rare before 5 years of IDDM: EURODIAB IDDM Complications Study Group and the WHO Multinational Study of Vascular Disease in Diabetes Study Group,” Journal of Diabetes and Its Complications, vol. 8, no. 3, pp. 166–173, 1994. View at Google Scholar
  9. M. L. Caramori, P. Fioretto, and M. Mauer, “Low glomerular filtration rate in normoalbuminuric type 1 diabetic patients: an indicator of more advanced glomerular lesions,” Diabetes, vol. 52, no. 4, pp. 1036–1040, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. R. J. MacIsaac, C. Tsalamandris, S. Panagiotopoulos, T. J. Smith, K. J. McNeil, and G. Jerums, “Non-albuminuric renal insufficiency in type 2 diabetes,” Diabetes Care, vol. 27, no. 1, pp. 195–200, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. H. J. Kramer, Q. D. Nguyen, G. Curhan, and C.-Y. Hsu, “Renal insufficiency in the absence of albuminuria and retinopathy among adults with type 2 diabetes mellitus,” The Journal of the American Medical Association, vol. 289, no. 24, pp. 3273–3277, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. A. S. Levey, J. Coresh, E. Balk et al., “National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification,” Annals of Internal Medicine, vol. 139, no. 2, pp. 137–I47, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. H. W. Smith, “The reliability of inulin as a measure of glomerular filtration,” in The Kidney: Structure and Function in Health and Disease, H. W. Smith, Ed., pp. 231–238, Oxford University Press, New York, NY, USA, 1951. View at Google Scholar
  14. D. W. Cockcroft and M. H. Gault, “Prediction of creatinine clearance from serum creatinine,” Nephron, vol. 16, no. 1, pp. 31–41, 1976. View at Publisher · View at Google Scholar · View at Scopus
  15. L. A. Stevens, J. Coresh, T. Greene, and A. S. Levey, “Assessing kidney function—measured and estimated glomerular filtration rate,” The New England Journal of Medicine, vol. 354, no. 23, pp. 2473–2483, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. A. S. Levey, L. A. Stevens, C. H. Schmid et al., “A new equation to estimate glomerular filtration rate,” Annals of Internal Medicine, vol. 150, no. 9, pp. 604–612, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. V. R. Dharnidharka, C. Kwon, and G. Stevens, “Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis,” American Journal of Kidney Diseases, vol. 40, no. 2, pp. 221–226, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. J. F. Roos, J. Doust, S. E. Tett, and C. M. J. Kirkpatrick, “Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children—a meta-analysis,” Clinical Biochemistry, vol. 40, no. 5-6, pp. 383–391, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. R. Hojs, S. Bevc, R. Ekart, M. Gorenjak, and L. Puklavec, “Serum crystatin C-based equation compared to serum creatinine-based equations for estimation of glomerular filtration rate in patient with chronic kidney disease,” Clinical Nephrology, vol. 70, no. 1, pp. 10–17, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. L. A. Stevens, J. Coresh, C. H. Schmid et al., “Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD,” American Journal of Kidney Diseases, vol. 51, no. 3, pp. 395–406, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. G. J. Chwartz, A. Munoz, and M. F. Schneide, “New equations to estimate GFR in children with CKD,” Journal of the American Society of Nephrology, vol. 20, no. 3, pp. 629–637, 2009. View at Publisher · View at Google Scholar · View at PubMed
  22. G. Jerums, E. Premaratne, S. Panagiotopoulos, S. Clarke, D. A. Power, and R. J. MacIsaac, “New and old markers of progression of diabetic nephropathy,” Diabetes Research and Clinical Practice, vol. 82, no. 1, pp. S30–S37, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. E. T. Rosolowsky, M. A. Niewczas, L. H. Ficociello, B. A. Perkins, J. H. Warram, and A. S. Krolewski, “Between hyperfiltration and impairment: demystifying early renal functional changes in diabetic nephropathy,” Diabetes Research and Clinical Practice, vol. 82, no. 1, pp. S46–S53, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. U. Pöge, T. Gerhardt, B. Stoffel-Wagner et al., “Cystatin C-based calculation of glomerular filtration rate in kidney transplant recipients,” Kidney International, vol. 70, no. 1, pp. 204–210, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. T. Le Bricon, E. Thervet, M. Benlakehal, B. Bousquet, C. Legendre, and D. Erlich, “Changes in plasma cystatin C after renal transplantation and acute rejection in adults,” Clinical Chemistry, vol. 45, no. 12, pp. 2243–2249, 1999. View at Google Scholar · View at Scopus
  26. T. Le Bricon, E. Thervet, M. Froissart et al., “Plasma cystatin C is superior to 24-h creatinine clearance and plasma creatinine for estimation of glomerular filtration rate 3 months after kidney transplantation,” Clinical Chemistry, vol. 46, no. 8, pp. 1206–1207, 2000. View at Google Scholar · View at Scopus
  27. H. Popper and H. Mandel, “Filtrations and reabsorption sleistung in der nievenpathologic,” Ergebnisse der inneren Medizin und Kinderheilkunde, vol. 53, p. 685, 1937. View at Google Scholar
  28. U. Pöge, T. Gerhardt, A. Bökenkamp et al., “Time course of low molecular weight proteins in the early kidney transplantation period—influence of corticosteroids,” Nephrology Dialysis Transplantation, vol. 19, no. 11, pp. 2858–2863, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. A. Haase-Fielitz, R. Bellomo, P. Devarajan et al., “Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery—a prospective cohort study,” Critical Care Medicine, vol. 37, no. 2, pp. 553–560, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. S. Herget-Rosenthal, G. Marggraf, J. Hüsing et al., “Early detection of acute renal failure by serum cystatin C,” Kidney International, vol. 66, no. 3, pp. 1115–1122, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. C. E. Mogensen and C. K. Christensen, “Predicting diabetic nephropathy in insulin-dependent patients,” The New England Journal of Medicine, vol. 311, no. 2, pp. 89–93, 1984. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. H. H. Parving, B. Oxenbøll, P. A. Svendsen, J. S. Christiansen, and A. R. Andersen, “Early detection of patients at risk of developing diabetic nephropathy. A longitudinal study of urinary albumin excretion,” Acta Endocrinologica, vol. 100, no. 4, pp. 550–555, 1982. View at Google Scholar · View at Scopus
  33. G. C. Viberti, R. J. Jarrett, and H. Keen, “Microalbuminuria as predictor of nephropathy in diabetics,” The Lancet, vol. 2, no. 8298, p. 611, 1982. View at Publisher · View at Google Scholar · View at Scopus
  34. G. D. Tan, A. V. Lewis, T. J. James, P. Altmann, R. P. Taylor, and J. C. Levy, “Clinical usefulness of cystatin C for the estimation of glomerular filtration rate in type 1 diabetes: reproducibility and accuracy compared with standard measures and iohexol clearance,” Diabetes Care, vol. 25, no. 11, pp. 2004–2009, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Buysschaert, I. Joudi, P. Wallemacq, and M. P. Hermans, “Performance of serum cystatin-C versus serum creatinine in subjects with type 1 diabetes,” Diabetes Care, vol. 26, no. 4, article 1320, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. A. G. Christensson, A. O. Grubb, J.-Å. Nilsson, K. Norrgren, G. Sterner, and G. Sundkvist, “Serum cystatin C advantageous compared with serum creatinine in the detection of mild but not severe diabetic nephropathy,” Journal of Internal Medicine, vol. 256, no. 6, pp. 510–518, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. L. Pucci, S. Triscornia, D. Lucchesi et al., “Cystatin C and estimates of renal function: searching for a better measure of kidney function in diabetic patients,” Clinical Chemistry, vol. 53, no. 3, pp. 480–488, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. I. H. de Boer, W. Sun, P. A. Cleary et al., “Longitudinal changes in estimated and measured GFR in type 1 diabetes,” Journal of the American Society of Nephrology, vol. 25, no. 4, pp. 810–818, 2014. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  39. R. G. Nelson, D. J. Pettitt, M. J. Carraher, H. R. Baird, and W. C. Knowler, “Effect of proteinuria on mortality in NIDDM,” Diabetes, vol. 37, no. 11, pp. 1499–1504, 1988. View at Publisher · View at Google Scholar · View at Scopus
  40. National Kidney Foundation, “KDOQI clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease,” American Journal of Kidney Diseases, vol. 49, no. 2, supplement 2, pp. S12–S179, 2007. View at Publisher · View at Google Scholar · View at PubMed
  41. M. Knapik-Kordecka, A. Piwowar, and M. Warwas, “Levels of cystatin C, activity of antipapain and antitrypsin in plasma of patients with diabetes mellitus type 2,” Wiadomości Lekarskie, vol. 53, no. 11-12, pp. 617–622, 2000. View at Google Scholar · View at Scopus
  42. M. Mussap, M. D. Vestra, P. Fioretto et al., “Cystatin C is a more sensitive marker than creatinine for the estimation of GFR in type 2 diabetic patients,” Kidney International, vol. 61, no. 4, pp. 1453–1461, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  43. O. A. Mojiminiyi, N. Abdella, and S. George, “Evaluation of serum cystatin C and chromogranin A as markers of nephropathy in patients with Type 2 diabetes mellitus,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 60, no. 6, pp. 483–489, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  44. O. A. Mojiminiyi and N. Abdella, “Evaluation of cystatin C and β-2 microglobulin as markers of renal function in patients with type 2 diabetes mellitus,” Journal of Diabetes and its Complications, vol. 17, no. 3, pp. 160–168, 2003. View at Publisher · View at Google Scholar · View at Scopus
  45. E. M. El-Shafey, G. F. El-Nagar, M. F. Selim, H. A. El-Sorogy, and A. A. Sabry, “Is serum cystatin C an accurate endogenous marker of glomerular filteration rate for detection of early renal impairment in patients with type 2 diabetes mellitus?” Renal Failure, vol. 31, no. 5, pp. 355–359, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  46. N. V. McNamara, R. Chen, M. R. Janu, P. Bwititi, G. Car, and M. Seibel, “Early renal failure detection by cystatin C in Type 2 diabetes mellitus: varying patterns of renal analyte expression,” Pathology, vol. 41, no. 3, pp. 269–275, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  47. S. Bevc, R. Hojs, R. Ekart, M. Završnik, M. Gorenjak, and L. Puklavec, “Simple cystatin C formula for estimation of glomerular filtration rate in overweight patients with diabetes mellitus type 2 and chronic kidney disease,” Experimental Diabetes Research, vol. 2012, Article ID 179849, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  48. S. J. Oh, J. I. Lee, W. C. Ha et al., “Comparison of cystatin C- and creatinine-based estimation of glomerular filtration rate according to glycaemic status in Type 2 diabetes,” Diabetic Medicine, vol. 29, no. 7, pp. e121–e125, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  49. Y. L. Jeon, M. H. Kim, W.-I. Lee, and S. Y. Kang, “Cystatin C as an early marker of diabetic nephropathy in patients with type 2 diabetes,” Clinical Laboratory, vol. 59, no. 11-12, pp. 1221–1229, 2013. View at Publisher · View at Google Scholar · View at Scopus
  50. X. Rao, M. Wan, C. Qiu, and C. Jiang, “Role of cystatin C in renal damage and the optimum cut-off point of renal damage among patients with type 2 diabetes mellitus,” Experimental and Therapeutic Medicine, vol. 8, no. 3, pp. 887–892, 2014. View at Google Scholar
  51. S.-H. Lee, S.-A. Park, S.-H. Ko et al., “Insulin resistance and inflammation may have an additional role in the link between cystatin C and cardiovascular disease in type 2 diabetes mellitus patients,” Metabolism: Clinical and Experimental, vol. 59, no. 2, pp. 241–246, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  52. W. Koenig, D. Twardella, H. Brenner, and D. Rothenbacher, “Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate,” Clinical Chemistry, vol. 51, no. 2, pp. 321–327, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  53. T. Jernberg, B. Lindahl, S. James, A. Larsson, L.-O. Hansson, and L. Wallentin, “Cystatin C: a novel predictor of outcome in suspected or confirmed non-ST-elevation acute coronary syndrome,” Circulation, vol. 110, no. 16, pp. 2342–2348, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  54. H. Strevens, D. Wide-Swensson, A. Grubb et al., “Serum cystatin C reflects glomerular endotheliosis in normal, hypertensive and pre-eclamptic pregnancies,” BJOG, vol. 110, no. 9, pp. 825–830, 2003. View at Publisher · View at Google Scholar · View at Scopus
  55. S. S. Panaich, V. Veeranna, C. Bavishi, S. K. Zalawadiya, A. Kottam, and L. Afonso, “Association of cystatin C with measures of obesity and its impact on cardiovascular events among healthy U. S. adults,” Metabolic Syndrome and Related Disorders, vol. 12, pp. 472–476, 2014. View at Publisher · View at Google Scholar · View at PubMed
  56. D. M. Maahs, L. G. Ogden, A. Kretowski et al., “Serum cystatin C predicts progression of subclinical coronary atherosclerosis in individuals with type 1 diabetes,” Diabetes Care, vol. 56, pp. 2774–2779, 2007. View at Google Scholar
  57. K. Sahakyan, K. E. Lee, A. Shankar, and R. Klein, “Serum cystatin C and the incidence of type 2 diabetes mellitus,” Diabetologia, vol. 54, no. 6, pp. 1335–1340, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  58. A. T. Reutens, F. Bonnet, O. Lantieri, R. Roussel, and B. Balkau, “The association between cystatin C and incident type 2 diabetes in relation to central adiposity,” Nephrology Dialysis Transplantation, vol. 28, no. 7, pp. 1820–1829, 2013, http://www.ncbi.nlm.nih.gov/pubmed/23291367. View at Publisher · View at Google Scholar · View at PubMed
  59. P. Wiesli, B. Schwegler, G. A. Spinas, and C. Schmid, “Serum cystatin C is sensitive to small changes in thyroid function,” Clinica Chimica Acta, vol. 338, no. 1-2, pp. 87–90, 2003. View at Publisher · View at Google Scholar · View at Scopus
  60. A. Bökenkamp, J. A. E. Van Wijk, M. J. Lentze, and B. Stoffel-Wagner, “Effect of corticosteroid therapy on serum cystatin C and β2-microglobulin concentrations,” Clinical Chemistry, vol. 48, no. 7, pp. 1123–1126, 2002. View at Google Scholar · View at Scopus