Effects of Low-Dose Pioglitazone on Serum Levels of Adiponectin, Dehydroepiandrosterone, Amyloid Beta Peptide, and Lipid Profile in Elderly Japanese People with Type 2 Diabetes
Table 2
Metabolic parameters before and after the add-on treatment of low-dose pioglitazone for 6 months (15 mg for males, 7.5 mg for females).
Male ()
Female ()
Total ()
Before
After
value
Before
After
value
Before
After
value
Body weight (kg)
61.4 ± 7.2
62.1 ± 7.2
0.099
50.0 ± 8.0
50.8 ± 7.9
0.062
55.7 ± 9.5
56.4 ± 9.3
0.010
HbA1c (%)
7.3 ± 0.6
7.0 ± 0.5
0.105
6.8 ± 0.7
6.9 ± 1.1
0.142
7.0 ± 0.7
6.9 ± 0.8
0.474
Casual plasma glucose (mg/dL)
189 ± 70
151 ± 50
0.124
169 ± 47
169 ± 52
0.958
179 ± 60
160 ± 51
0.199
Casual serum levels of
LDL cholesterol (mg/dL)
105 ± 27
110 ± 29
0.214
109 ± 20
115 ± 20
0.379
107 ± 23
113 ± 25
0.148
Small dense LDL-C (mg/dL)
23.8 ± 12.6
25.5 ± 13.4
0.201
24.2 ± 7.8
24.2 ± 10.2
0.993
24.0 ± 10.3
24.8 ± 11.7
0.645
HDL cholesterol (mg/dL)
45.3 ± 6.7
48.3 ± 7.1
0.132
50.5 ± 11.0
53.8 ± 12.2
0.035
48.0 ± 9.3
51.0 ± 10.1
0.009
Triglyceride (mg/dL)
118 ± 7
125 ± 58
0.717
136 ± 38
117 ± 28
0.154
127 ± 50
121 ± 45
0.584
Free fatty acid (μEq/L)
260 ± 225
223 ± 165
0.497
283 ± 219
258 ± 175
0.589
272 ± 218
240 ± 167
0.370
Arachidonic acid (μg/mL)
111 ± 30
123 ± 28
0.021
129 ± 47
143 ± 35
0.108
120 ± 39
133 ± 33
0.007
Eicosapentaenoic acid (μg/mL)
44.4 ± 19.3
54.0 ± 24.4
0.015
49.9 ± 27.8
44.0 ± 20.9
0.280
47.2 ± 23.6
49.0 ± 22.8
0.610
Docosahexaenoic acid (μg/mL)
106 ± 30
119 ± 35
0.082
111 ± 20
117 ± 19
0.730
113 ± 30
118 ± 28
0.300
LDL-C: low-density lipoprotein cholesterol; HDL: high-density lipoprotein; , by two-sided paired -test. Doses of sulfonylurea were reduced in 6 male patients and in 4 female patients.
