Effects of Low-Dose Pioglitazone on Serum Levels of Adiponectin, Dehydroepiandrosterone, Amyloid Beta Peptide, and Lipid Profile in Elderly Japanese People with Type 2 Diabetes
Table 3
Serum levels of adiponectin, dehydroepiandrosterone, C-reactive protein, and amyloid beta before and after 6-month add-on treatment of low-dose pioglitazone (15 mg for males, 7.5 mg for females).
Male ()
Female ()
Total ()
Before
After
value
Before
After
value
Before
After
value
High-molecular-weight adiponectin (μg/mL)
4.7 ± 3.2
12.3 ± 6.9
<0.001
6.3 ± 3.0
12.3 ± 4.6
<0.001
5.5 ± 3.2
12.3 ± 5.7
<0.001
Dehydroepiandrosterone sulphate (μg/dL)
95.8 ± 52.0
89.8 ± 48.4
0.265
72.1 ± 40.5
62.5 ± 33.1
0.061
84.0 ± 47.2
76.2 ± 42.9
0.030
High-sensitivity C-reactive protein (μg/L)
934 ± 1022
833 ± 1298
0.840
877 ± 1141
520 ± 290
0.248
905 ± 1060
676 ± 934
0.424
Amyloid beta peptide 1–40 (pmol/L)
49.8 ± 10.9
49.2 ± 8.9
0.789
42.5 ± 15.4
50.0 ± 11.4
0.062
46.1 ± 13.6
49.6 ± 10.0
0.132
Amyloid beta peptide 1–42 (pmol/L)
2.8 ± 0.8
2.6 ± 0.8
0.656
2.9 ± 1.6
3.3 ± 1.4
0.272
2.9 ± 1.2
2.9 ± 1.1
0.713
, by two-sided paired -test. Doses of sulfonylurea were reduced in 6 male patients and in 4 female patients.
