Table of Contents
Advances in Endocrinology
Volume 2017 (2017), Article ID 9239386, 6 pages
https://doi.org/10.1155/2017/9239386
Research Article

The Efficacy of Anastrozole and Growth Hormone Therapy on Adult Height in Six Adolescent Males with Growth Hormone Deficiency or Idiopathic Short Stature

Division of Pediatric Endocrinology, Rhode Island Hospital and Warren Alpert School of Brown University, Providence, RI, USA

Correspondence should be addressed to Jose Bernardo Quintos; ude.nworb@sotniuqbj

Received 24 March 2017; Accepted 26 April 2017; Published 22 May 2017

Academic Editor: Rosaria Meccariello

Copyright © 2017 Serife Uysal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Data on adult height outcomes of the use of Anastrozole and Growth Hormone (GH) in pubertal males with Growth hormone deficiency (GHD) and Idiopathic short stature (ISS) are limited. Objective. We examined the effect of Anastrozole and GH therapy on near adult height (NAH) with pubertal males with GHD or ISS. Methods. Retrospective review of 419 charts from 2008 to 2015. The primary outcomes are NAH compared to mid-parental target height (MPTH) and predicted adult height (PAH). Results. We identified 23 patients (5 SGA/IUGR, 1 Noonan syndrome, 6 GHD, and 11 ISS). Six patients (4 GHD; 2 ISS) achieved NAH. Prior to Anastrozole treatment, the mean chronological age was years (range 13.7–14.4), bone age was years (range 12.5–14), mean height SDS was (range −0.8 to −2.3), and mean PAH was  cm (range 153.5–168.6). MPTH was 173.6 cm ± 7 (range 161.8–181.6). Patients received Anastrozole for an average of 30.5 months (range 19–36 months). At NAH, the mean chronological age was years (range 15.9–18.1 years) and height was  cm (range 168.5–173.4 cm). The mean height SDS improved to (range +0.08 to +1.92, ). Net height gain was 7.3 cm compared to pretreatment PAH () and overall the mean adult height remained 3.5 cm below MPTH. Conclusion. Anastrozole and GH therapy can be effective in augmenting adult height without significant side effects. However, the long-term safety and efficacy of aromatase inhibitor use in pediatrics remain limited.