The Efficacy of Anastrozole and Growth Hormone Therapy on Adult Height in Six Adolescent Males with Growth Hormone Deficiency or Idiopathic Short Stature

Table 1

Baseline clinical characteristics of study patients before initiation of GH therapy.

Patient #	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6	Mean
Diagnosis	ISS	GHD	ISS	ISS	ISS	GHD	N/A
Chronological age (yr)	13.0	9.6	13.1	12.4	13.9	8.0	11.7 ± 2.3
Bone age (yr)	11.5	10	10	13	14	6	10.7 ± 2.8
Height (cm)	139.5	123	136.6	135.1	145.2	112.6	132 ± 11.9
Height SDS	−2.1	−2.2	−2.6	−2.3	−2.2	−2.7	−2.3 ± 0.24
Weight (kg)	34.9	26.9	31	35.2	36.5	19.9	30.7 ± 6.3
Weight SDS	−1.4	−0.9	−2.3	−1.0	−1.9	−1.9	−1.6 ± 0.5
Body Mass Index (kg/m^2)	17.9	17.7	16.6	19.2	17.3	15.7	17.4 ± 1.1
BMI SDS	−0.2	−0.5	−0.9	0.4	−0.8	−0.04	−0.16 ± 0.6
Growth velocity (cm/yr)	6.3	3	2.6	N/A	5.1	4	4.2 ± 1.5
Peak GH level (ng/mL)	7.9	4.5	9.2	N/A	N/A	3.2	N/A
Tanner stage
Pubic hair	2	1	2	1	3	1	N/A
Genitalia	2	1	2	1	3	1	N/A
Testicle size (cc)	6–8	3	6	3	10	2-3	N/A
PAH (cm)	165.6	156.5	167.4	154.9	157.5	162	160.6 ± 4.6
MPTH (cm)	181.6	161.8	170.3	179.2	174.1	174.6	173.6 ± 7
MPTH SDS	0.7	−2.0	−0.9	0.3	0.4	−0.3	−0.3 ± 1