Oxidative Stress and Proteostasis Network: Culprit and Casualty of Alzheimer’s-Like Neurodegeneration

Table 1

List of the proteins members of the proteostasis networks identified oxidatively modified in Alzheimer's-like diseases.

Proteostasis system	Oxidized proteins	Disease
Molecular chaperones	HSP90	AD [5]
	HSP60	AD [5]
	HSP32	AD [87]
	Haptoglobin	AD [94]
	Alpha 2 macroglobulin	AD [94]
	Serum amyloid P	AD [94]
	Clusterin	AD [94]
	HSC71	DS/AD [80]
ER proteins	EF-Tu	AD [101]
	eIF-a	AD [101]
	Pin1	AD [106]
	GRP78	DS, DS/AD [80, 81]
Ubiquitin-proteasome system	UCH-L1	AD [97], DS/AD, and; DS [80, 81]
Autophagy-lysosome system	Cathepsin D	DS [81]
	V0-ATPase	DS [81]
	GFAP	DS, DS/AD [80, 81]