Table of Contents
Asian Journal of Neuroscience
Volume 2014, Article ID 891653, 7 pages
http://dx.doi.org/10.1155/2014/891653
Research Article

Polymorphisms in the Sortilin-Related Receptor 1 Gene Are Associated with Cognitive Impairment in Filipinos

1Research and Biotechnology, St. Luke’s Medical Center, 279 E Rodriguez Sr. Boulevard, 1112 Quezon City, Philippines
2St. Luke’s College of Medicine William H. Quasha Memorial, E Rodriquez Sr. Boulevard, 1112 Quezon City, Philippines
3Memory Center, Institute for Neuroscience, St. Luke’s Medical Center, 279 E Rodriquez Sr. Boulevard, 1112 Quezon City, Philippines

Received 6 August 2014; Revised 23 October 2014; Accepted 6 November 2014; Published 27 November 2014

Academic Editor: Raymond Chuen-Chung Chang

Copyright © 2014 Cristine R. Casingal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background/Aims. Sortilin-related receptor 1 (SORL1) is involved in the neuronal transport processes and plays a role in the formation of amyloid plaques. This study investigated the association of 6 SORL1 single nucleotide polymorphisms (SNPs 8, 9, 10, 13, 19, and 23) with cognitive impairment (CI) in Filipinos. Methods. DNA samples from 484 subjects (100 Alzheimer’s Disease (AD) cases, 109 mild cognitive impairment (MCI) cases, 18 other types of CI, and 257 no dementia controls (NDC)) were genotyped using TaqMan SNP Genotyping Assays. Data Analysis. Our study showed strong linkage disequilibrium in the SNPs 8, 9, and 10 block. Our results showed that CI was significantly associated with SNPs 13 and 23. None of the SORL1 SNPs studied was associated with AD while SNPs 8, 9, 10, and 23 were associated with MCI. Conclusion. The findings had provided evidence that SORL1 may predispose individuals to CI. Further studies are needed to clarify the role of SORL1 in Filipinos with AD.