Polymorphisms in the Sortilin-Related Receptor 1 Gene Are Associated with Cognitive Impairment in Filipinos

Table 1

Goodness-of-fit to HWE for the elderly Filipinos studied.

SNP#	Observed			Total	obs	obs				exp	exp	exp	χ^2
8	CC	TC	TT
	56	204	224	484	0.3265	0.6735	0.1066	0.4398	0.4537	52	213	219	0.8355
9	AA	GA	GG
	224	203	57	484	0.6725	0.3275	0.4523	0.4405	0.1072	219	213	52	1.1056
10	AA	GA	GG
	224	203	57	484	0.6725	0.3275	0.4523	0.4405	0.1072	219	213	52	1.1056
13	AA	GA	GG
	7	60	417	484	0.0764	0.9236	0.0058	0.1412	0.8530	3	68	413	7.2127^*
19	TT	TG	GG
	75	218	191	484	0.3802	0.6198	0.1445	0.4713	0.3842	70	228	186	0.9488
23	TT	TA	AA
	89	227	168	484	0.4184	0.5816	0.1750	0.4867	0.3383	85	235	164	0.6381

Legend:
χ ² tabulated (dF = 1, = 0.05): 3.841.
obs: observed frequency of homozygous Allele 1.
obs: observed frequency of homozygous Allele 2.
exp: expected frequency of homozygous Allele 1.
exp: expected frequency of homozygous Allele 2.
exp: expected frequency of heterozygotes.
^*Genotypic and allelic frequencies are not in Hardy-Weinberg equilibrium.
If χ² calculated < χ² tabulated, do not reject null hypothesis.
If χ² calculated > χ² tabulated, reject null hypothesis.