Table of Contents
Advances in Nephrology
Volume 2014, Article ID 573685, 10 pages
Review Article

Peritoneal Membrane Injury and Peritoneal Dialysis

Department of Medicine, McMaster University, Division of Nephrology, St. Joseph’s Hospital, 50 Charlton Avenue E, Hamilton, ON, Canada L8P 4A6

Received 6 July 2014; Revised 24 September 2014; Accepted 29 September 2014; Published 2 November 2014

Academic Editor: Lawrence H. Lash

Copyright © 2014 Shaan Chugh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


For patients with chronic renal failure, peritoneal dialysis (PD) is a common, life sustaining form of renal replacement therapy that is used worldwide. Exposure to nonbiocompatible dialysate, inflammation, and uremia induces longitudinal changes in the peritoneal membrane. Application of molecular biology techniques has led to advances in our understanding of the mechanism of injury of the peritoneal membrane. This understanding will allow for the development of strategies to preserve the peritoneal membrane structure and function. This may decrease the occurrence of PD technique failure and improve patient outcomes of morbidity and mortality.