Deleterious Effects of Increased Intra-Abdominal Pressure on Kidney Function

Figure 2

Effects of 7 and 14 mmHg insufflations with CO₂ on glomerular filtration rate (GFR) (a) and renal plasma flow (RPF) (b). Note that only IAP of 14 mmHg was effective in attenuating IAP-induced renal hemodynamics alterations. () versus baseline, () versus U2-7 mmHg, ($) versus U3-7 mmHg, Effects of nitroglycerine on pneumoperitoneum- (IAP = 14 mmHg) induced renal hemodynamic alterations. Glomerular filtration rate (GFR) (c) and renal plasma flow (RPF) (d) in nitroglycerine treated rats as compared with untreated animals (controls). Note that nitroglycerine was effective in attenuating the pneumoperitoneum-induced reduction in renal hemodynamic alterations. () versus baseline; () versus untreated pneumoperitoneum. Effects of L-NAME on pneumoperitoneum- (IAP = 14 mmHg) induced renal hemodynamic alterations. Glomerular filtration rate (GFR) (e) and renal plasma flow (RPF) (f) in L-NAME treated rats as compared with untreated animals (controls). Note that L-NAME treatment aggravated the pneumoperitoneum-induced reductions in GFR and RPF. () versus baseline; () versus untreated pneumoperitoneum [5, 6].

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