Predictors of a Rapid Decline of Renal Function in Patients with Chronic Kidney Disease Referred to a Nephrology Outpatient Clinic: A Longitudinal Study
Table 2
Baseline characteristics of patients with and without rapid kidney function decline, defined by an annual loss of >4 mL/min/1.73 m2 in creatinine-based estimated glomerular filtration rate.
No rapid decline Annual loss ≤ 4 mL/min/1.73 m2
Rapid decline Annual loss > 4 mL/min/1.73 m2
value
Sex (male %)
116 (56)
47 (66.7)
0.134
Age > 65 years (%)
180 (87)
54 (85.7)
0.800
Age (years)
75.2 ± 8.7
74.2 ± 8.9
0.589
Previous CV event (%)
64 (30.9)
28 (44.4)
0.047
Serum creatinine (mg/dL)
1.5 ± 0.3
1.5 ± 0.5
0.068
Serum uric acid (mg/dL)
6.9 ± 1.7
7.0 ± 1.5
0.679
Haemoglobin (g/dL)
13.2 ± 1.5
13.1 ± 1.6
0.329
Body mass index (kg/m2)
29.9 ± 4.6
30.2 ± 5.5
0.592
(mL/min/1.73 m2)
39 ± 12
41 ± 14
0.290
Systolic blood pressure (mm Hg)
138 ± 19
138 ± 18
0.588
Diastolic blood pressure (mm Hg)
76 ± 10
76 ± 14
0.994
Glucose (mg/dL)
116 ± 35
124 ± 46
0.125
Total cholesterol (mg/dL)
189 ± 41
181 ± 38
0.162
Serum triglycerides (mg/dL)
150 ± 118
160 ± 91
0.606
Proteinuria (g/24 h)
0.23 ± 0.53
0.77 ± 1.27
<0.001
Serum albumin (g/dL)
4.2 ± 0.3
4.1 ± 0.3
0.004
HbA1c (%)
7 ± 1.7
7.5 ± 1.5
0.170
HDL cholesterol (mg/dL)
50 ± 16
52 ± 17
0.583
LD cholesterol (mg/dL)
109 ± 35
101 ± 35
0.247
Serum cystatin C (g/L)
1.71 ± 0.54
1.73 ± 0.46
0.770
Diabetes mellitus, (%)
79 (38.3)
35 (55.6)
0.016
Tobacco use, (%)
95 (46.9)
36 (57.1)
0.118
CV: cardiovascular; : estimated glomerular filtration rate according to creatinine; HbA1c: glycated haemoglobin. Data are presented as (%). Data are presented as the mean ± SD. Performed in diabetic patients only.
