Contemporary Review of the Management of Brain Metastasis with Radiation

Table 1

Dose fractionation schemes of WBRT in various tumor types.

Study	Number of patients	Randomization Gy/# fractions	Median survival (months)
Harwood and Simpson [18]	101	30/10 versus 10/1	4.0–4.3
Kurtz et al. [19]	255	30/10 versus 50/20	3.9–4.2
Borgelt et al. [17, 20]	138	10/1 versus 30/10 versus 40/20	4.2–4.8
Borgelt et al. [17, 20]	64	12/2 versus 20/5	2.8–3.0
Chatani et al. [21]	70	30/10 versus 50/20	3.0–4.0
Haie-Meder et al. [22]	216	18/3 versus 36/6 or 43/13	4.2–5.3
Chatani et al. [23]	72	30/10 versus 50/20 or 20/5	2.4–4.3
Murray et al. [24]	445	54.4/34 versus 30/10	4.5

Adapted from Khuntia et al. [25].