Contemporary Review of the Management of Brain Metastasis with Radiation

Table 3

RTOG 9005 [29].

Tumor diameter ≤20 mm		21–30 mm		31–40 mm
Dose	Toxicity	Dose	Toxicity	Dose	Toxicity
18 Gy	8%	15 Gy	13%	12 Gy	10%
21 Gy	11%	18 Gy	20%	15 Gy	14%
24Gy	10%	21 Gy	38%	18 Gy	50%
		24 Gy	58%

The MTD for tumors ≤20 mm is 24 Gy, for tumors 21–30 mm it is 18 Gy, and for tumors 31–40 mm it is 15 Gy. Doses in yellow represent the recommended MTD.