Advances in Neuroscience / 2015 / Article / Tab 4

Review Article

Contemporary Review of the Management of Brain Metastasis with Radiation

Table 4

RTOG 9508 [30]. SRS improved survival in patients with a single BrM. Subset analysis suggested there was a potential benefit for patients with NSCLC, RPA class I, or patients that were <50 years old with 2 to 3 metastasis. Patients in the study receiving SRS also had improved KPS with decreased steroid dependence.

Med OSAll ptsSingle brain met1–3 mets, age <501–3 mets, NSCLC1–3 mets, RPA class I

WBRT alone5.7 mos4.9 months8.3 months3.9 months9.6 months
WBRT + SRS6.5 mos6.5 months9.9 months5.0 months11.6 months
value0.140.040.040.050.05

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