Contemporary Review of the Management of Brain Metastasis with Radiation

Table 5

JROSG 99-1 [31] study comparing SRS with or without WBRT. Omission of WBRT was found to decrease intracranial control, and, as a result, the authors recommended SRS + WBRT for patients with up to 4 brain metastases.

	MS	OS @ 1 yr	Freedom from new brain mets @ 1 mos	Salvage brain tx	Neuro death
SRS	8.0 months	28.4%	46.8%	43%	19.3%
SRS + WBRT	7.5 months	38.5%	76.4%	15%	22.8%
value	0.42	0.42	<0.001	<0.001	0.64