Advances in Neuroscience / 2015 / Article / Tab 5

Review Article

Contemporary Review of the Management of Brain Metastasis with Radiation

Table 5

JROSG 99-1 [31] study comparing SRS with or without WBRT. Omission of WBRT was found to decrease intracranial control, and, as a result, the authors recommended SRS + WBRT for patients with up to 4 brain metastases.

MSOS @ 1 yrFreedom from new brain mets @ 1 mosSalvage brain txNeuro death

SRS8.0 months28.4%46.8%43%19.3%
SRS + WBRT7.5 months38.5%76.4%15%22.8%
value0.420.42<0.001<0.0010.64

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