Neurofilament and Brain Atrophy and Their Association with Cognition in Multiple Sclerosis: A 10-Year Follow-Up Study

Figure 2

Predicted values of SDMT for the 10th (diamonds, black dotted line), 50th (squares, dark gray dashed line), and 90th (triangles, light gray solid line) percentile values at baseline of (a) log-transformed sNfL, (b) square-rooted T1 lesion volume, and (c) EDSS. Percentile values for log-transformed sNfL were 1.81, 2.47, and 3.54, corresponding to concentrations of 6.1, 11.8, and 34.5 pg/mL. Percentile values for square-rooted T1 lesion volumes were 0.41, 1.86, and 4.21, corresponding to volumes of 0.2, 3.5, and 17.7 mL. Percentile values for EDSS were 1.5, 3.5, and 4.5. Results from linear mixed modelling with time (baseline, five years, 10 years) as a categorical variable. Covariate values fixed at female sex, age at baseline 41 years, no higher education, disease duration 60 months. Abbreviation: SDMT: symbol digit modalities test; sNfL: serum neurofilament light chain; CI: confidence interval.

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