Increased ¹⁸F-THK5351 Uptake at Bilateral Primary Motor Cortex in Patients with Progressive Pseudobulbar Palsy

Figure 1

Brain MRI and ¹⁸F-THK5351 PET images of patients with progressive pseudobulbar palsy. (a) T1-weighted brain MRI images of Patient 1. Mild bilateral frontal lobe dominant brain atrophy is observed without accent in the precentral gyrus. (b) ¹⁸F-THK5351 PET images of Patient 1, (c) overlayed images on brain MRI, (d) and 3D renderings on individual brain structures. Bilateral increased uptake is observed in limited areas of the posterior portion of the precentral gyrus, corresponding to the midportion of the primary motor cortex. (b, c) Although the distribution was symmetric, uptake was slightly higher on the left side. (e) T1-weighted brain MRI images of Patient 2. Apparent focal atrophy is not observed. (f) ¹⁸F-THK5351 PET images of patient 2, (g) overlayed images on brain MRI, (h) and 3D renderings. Right-dominant bilateral increased uptake is observed in limited areas of the posterior portion of the precentral gyrus, corresponding to the midportion of the primary motor cortex. Color scales represent the uptake ratio index (URI), with the cerebellum as the reference region (=1). Red areas in (d) and (h) are cerebral regions with . R: right; L: left.