Increased ¹⁸F-THK5351 Uptake at Bilateral Primary Motor Cortex in Patients with Progressive Pseudobulbar Palsy

Figure 2

Striatal and midbrain imaging findings of Patient 2. (a) Average ¹⁸F-THK5351 PET images of healthy volunteers. Symmetric physiological tracer uptake is observed in striatum, thalamus, periaqueductal gray, and substantia nigra as previously reported [15]. (b) ¹⁸F-THK5351 PET images and (c) overlayed images of Patient 2. Although tracer uptake is observed in these regions, uptake in the substantia nigra and striatum was higher on the right side. (d) Dopamine transporter SPECT results using ¹²³I-ioflupane as a tracer analyzed by DAT VIEW software. Tracer uptake was visually decreased in the right dorsal putamen. The specific binding ratio (SBR) after phantom calibration was right 4.21 and left 4.44, which were both below 2 standard deviations from age- and sex-matched controls. R: right; L: left.