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Advances in Optical Technologies
Volume 2008 (2008), Article ID 267867, 8 pages
Research Article

Optical Clearing of Cranial Bone

1Research-Educational Institute of Optics and Biophotonics, Saratov State University, Astrakhanskaya Street, 83, Saratov 410012, Russia
2Laser Diagnostics of Technical and Living Systems Lab, Institute of Precise Mechanics and Control of RAS, 24 Rabochaya Street, Saratov 410028, Russia

Received 20 February 2008; Accepted 2 April 2008

Academic Editor: Stoyan Tanev

Copyright © 2008 Elina A. Genina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We present experimental results on optical properties of cranial bone controlled by administration of propylene glycol and glycerol. Both transmittance and reflectance spectra of human and porcine cranial bone in vitro were measured. For estimation of absorption and reduced scattering coefficients of the bone, the inverse adding-doubling method was used. The decrease of reflectance of the samples under action of the immersion agents was demonstrated. The experiments have shown that administration of the immersion liquids allows for effective controlling of tissue optical characteristics that makes bone more transparent, thereby increasing the ability of light penetration through the tissue. The presented results can be used in developing of functional imaging techniques, including OCT.