Evaluation of Autogenous Engineered Septal Cartilage Grafts in Rabbits: A Minimally Invasive Preclinical Model

Figure 2

Immunohistochemical staining for type I and type II collagen in in vitro control neocartilage constructs (top) or after 30 days in vivo (below). Sections were counterstained with the nuclear stain methyl green. Neocartilage constructs had robust staining for both collagen types II and I (left and middle) compared with the nonspecific control IgG (right). In addition, in vivo tissue had enlarged lacunae containing large clusters of cells.