Development and Validation of Acyclovir HPLC External Standard Method in Human Plasma: Application to Pharmacokinetic Studies

Table 5

Stability studies.

Nominal concentration ng/mL ()	Concentration found ng/mL	Precision (%)	Accuracy (%)
Short-term stability for 3 h in plasma
25.0	24.5612	2.01	98.43
150.0	148.9627	2.54	94.59
Long-term stability for 3 h in plasma
25.0	23.6984	2.57	93.52
150.0	146.9013	3.18	92.04
Freeze-thaw cycles (−70^°C)
25.0	23.98	3.21	95.52
150.0	147.74	8.54	92.47