Table of Contents
Advances in Pharmaceutics
Volume 2014, Article ID 468456, 12 pages
http://dx.doi.org/10.1155/2014/468456
Research Article

Nanoemulsion Based Hydrogel for Enhanced Transdermal Delivery of Ketoprofen

Rayat & Bahra Institute of Pharmacy, Sahauran, Mohali, Punjab 140104, India

Received 30 July 2014; Accepted 14 November 2014; Published 16 December 2014

Academic Editor: Cornelia M. Keck

Copyright © 2014 Ritika Arora et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Singh, R. Singh, S. Bandyopadhyay, R. Kapil, and B. Garg, “Optimized nanoemulsifying systems with enhanced bioavailability of carvedilol,” Colloids and Surfaces B: Biointerfaces, vol. 101, pp. 465–474, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. J.-H. Zhao, L. Ji, H. Wang et al., “Microemulsion-based novel transdermal delivery system of tetramethylpyrazine: preparation and evaluation in vitro and in vivo,” International Journal of Nanomedicine, vol. 6, pp. 1611–1619, 2011. View at Google Scholar · View at Scopus
  3. K. W. Ambade, S. L. Jadhav, M. N. Gambhire, S. D. Kurmi, V. J. Kadam, and K. R. Jadhav, “Formulation and evaluation of flurbiprofen microemulsion,” Current Drug Delivery, vol. 5, no. 1, pp. 32–41, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. E. Yilmaz and H.-H. Borchert, “Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema—an in vivo study,” International Journal of Pharmaceutics, vol. 307, no. 2, pp. 232–238, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Adachi, F. Ioppolo, M. Paoloni, and V. Santilli, “Physical characteristics, pharmacological properties and clinical efficacy of the ketoprofen patch: a new patch formulation,” European Review for Medical and Pharmacological Sciences, vol. 15, no. 7, pp. 823–830, 2011. View at Google Scholar · View at Scopus
  6. F. Glówka, M. Karaźniewicz-Lada, E. Grześkowiak, D. Rogozinska, and W. Romanowski, “Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis,” European Journal of Drug Metabolism and Pharmacokinetics, vol. 36, no. 3, pp. 167–173, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Shinkai, K. Korenaga, Y. Okumura, H. Mizu, and H. Yamauchi, “Microdialysis assessment of percutaneous penetration of ketoprofen after transdermal administration to hairless rats and domestic pigs,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 78, no. 3, pp. 415–421, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. P. K. Shetty, N. A. Suthar, J. Menon et al., “Transdermal delivery of lercanidipine hydrochloride: effect of chemical enhancers and ultrasound,” Current Drug Delivery, vol. 10, no. 4, pp. 427–434, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Baboota, F. Shakeel, A. Ahuja, J. Ali, and S. Shafiq, “Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib,” Acta Pharmaceutica, vol. 57, no. 3, pp. 315–332, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Mou, H. Chen, D. Du et al., “Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs,” International Journal of Pharmaceutics, vol. 353, no. 1-2, pp. 270–276, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Chen, X. Chang, D. Du, J. Li, H. Xu, and X. Yang, “Microemulsion-based hydrogel formulation of ibuprofen for topical delivery,” International Journal of Pharmaceutics, vol. 315, no. 1-2, pp. 52–58, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. W. Zhu, C. Guo, A. Yu, Y. Gao, F. Cao, and G. Zhai, “Microemulsion-based hydrogel formulation of penciclovir for topical delivery,” International Journal of Pharmaceutics, vol. 378, no. 1-2, pp. 152–158, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Aggarwal, S. Dhawan, and S. L. Harikumar, “Formulation, in vitro, and in vivo evaluation of matrix-type transdermal patches containing olanzapine,” Pharmaceutical Development and Technology, vol. 18, no. 4, pp. 916–925, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. V. Ntimenou, A. Fahr, and S. G. Antimisiaris, “Elastic vesicles for transdermal drug delivery of hydrophilic drugs: a comparison of important physicochemical characteristics of different vesicle types,” Journal of Biomedical Nanotechnology, vol. 8, no. 4, pp. 613–623, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. G. N. El-Hadidy, H. K. Ibrahim, M. I. Mohamed, and M. F. El-Milligi, “Microemulsions as vehicles for topical administration of voriconazole: formulation and in vitro evaluation,” Drug Development and Industrial Pharmacy, vol. 38, no. 1, pp. 64–72, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. W. Liu, R. Tian, W. Hu et al., “Preparation and evaluation of self-microemulsifying drug delivery system of baicalein,” Fitoterapia, vol. 83, no. 8, pp. 1532–1539, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Mura, M. Manconi, D. Valenti, C. Sinico, A. O. Vila, and A. M. Fadda, “Transcutol containing vesicles for topical delivery of minoxidil,” Journal of Drug Targeting, vol. 19, no. 3, pp. 189–196, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Ngawhirunpat, N. Worachun, P. Opanasopit, T. Rojanarata, and S. Panomsuk, “Cremophor RH40-PEG 400 microemulsions as transdermal drug delivery carrier for ketoprofen,” Pharmaceutical Development and Technology, vol. 18, no. 4, pp. 798–803, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Chen, D. Mou, D. Du et al., “Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration,” International Journal of Pharmaceutics, vol. 341, no. 1-2, pp. 78–84, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Aboofazeli, D. J. Barlow, and M. J. Lawrence, “Particle size analysis of concentrated phospholipid microemulsions: I. Total intensity light scattering,” AAPS PharmSci, vol. 2, no. 2, pp. 1–13, 2000. View at Google Scholar · View at Scopus
  21. B. Biruss, H. Kählig, and C. Valenta, “Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones,” International Journal of Pharmaceutics, vol. 328, no. 2, pp. 142–151, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Jiao and D. J. Burgess, “Rheology and stability of water-in-oil-in-water multiple emulsions containing span 83 and tween 80,” AAPS PharmSci, vol. 5, no. 1, pp. 62–73, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Kaushik, P. Batheja, B. Kilfoyle, V. Rai, and B. Michniak-Kohn, “Percutaneous permeation modifiers: enhancement versus retardation,” Expert Opinion on Drug Delivery, vol. 5, no. 5, pp. 517–529, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Shinoda and B. Lindman, “Organized surfactant systems: microemulsions,” Langmuir, vol. 3, no. 2, pp. 135–149, 1987. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Azeem, M. Rizwan, F. J. Ahmad et al., “Nanoemulsion components screening and selection: a technical note,” AAPS PharmSciTech, vol. 10, no. 1, pp. 69–76, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. C. H. Lee, V. Moturi, and Y. Lee, “Thixotropic property in pharmaceutical formulations,” Journal of Controlled Release, vol. 136, no. 2, pp. 88–98, 2009. View at Publisher · View at Google Scholar · View at Scopus