Table of Contents
Advances in Pharmaceutics
Volume 2014, Article ID 574673, 12 pages
http://dx.doi.org/10.1155/2014/574673
Review Article

Lipid Based Vesicular Drug Delivery Systems

Mahakal Institute of Pharmaceutical Studies, Behind Air Strip, Datana, Dewas Road, Ujjain, Madhya Pradesh 456664, India

Received 30 June 2014; Revised 20 August 2014; Accepted 21 August 2014; Published 2 September 2014

Academic Editor: Changyang Gong

Copyright © 2014 Shikha Jain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Vesicular drug delivery system can be defined as highly ordered assemblies consisting of one or more concentric bilayers formed as a result of self-assembling of amphiphilic building blocks in presence of water. Vesicular drug delivery systems are particularly important for targeted delivery of drugs because of their ability to localize the activity of drug at the site or organ of action thereby lowering its concentration at the other sites in body. Vesicular drug delivery system sustains drug action at a predetermined rate, relatively constant (zero order kinetics), efficient drug level in the body, and simultaneously minimizes the undesirable side effects. It can also localize drug action in the diseased tissue or organ by targeted drug delivery using carriers or chemical derivatization. Different types of pharmaceutical carriers such as polymeric micelles, particulate systems, and macro- and micromolecules are presented in the form of novel drug delivery system for targeted delivery of drugs. Particulate type carrier also known as colloidal carrier system, includes lipid particles, micro- and nanoparticles, micro- and nanospheres, polymeric micelles and vesicular systems like liposomes, sphingosomes, niosomes, transfersomes, aquasomes, ufasomes, and so forth.