Applications of Potential Energy Surfaces in the Study of Enzymatic Reactions

<table>Chemical model used in the study on the mechanism of AlkB. The substrate and cosubstrate (<i>α</i>-KG) are modeled as 3-methyl-4-amino pyrimidinyl cation and pyruvate, respectively. Atoms marked by an * were held fixed at their crystal structure (PDB: 2FD8) positions [<a href="/journals/apc/2012/867409/#B23">21</a>].</table>

Advances in Physical Chemistry

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Scheme 3

Scheme 3: Applications of Potential Energy Surfaces in the Study of Enzymatic Reactions 