Table of Contents
Advances in Psychiatry
Volume 2014, Article ID 493505, 7 pages
Review Article

Cytokine Serum Levels as Potential Biological Markers for the Psychopathology in Schizophrenia

South Texas Veterans Health Care Systems, San Antonio, TX 78229-4404, USA

Received 25 August 2014; Accepted 27 November 2014; Published 11 December 2014

Academic Editor: Livia Carvalho

Copyright © 2014 Dimitre H. Dimitrov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We discuss the role of immune system disturbance in schizophrenia and especially changes of serum levels of cytokines in patients with schizophrenia. The cytokines are essential to wide range of functions related to the defense of the organisms from infectious and environmental dangers. However it is not known whether cytokines influence the presentation of psychotic symptoms. Identification of changes in the serum level of certain cytokines and their correlation with distinct psychopathological symptoms may facilitate the identification of subgroups of patients who are likely to benefit from immunotherapy or anti-inflammatory therapy. Such patients may benefit from tailored immunotherapy designed for modulation of abnormal cytokine levels related to specific positive or negative symptoms of schizophrenia.