Evaluating pH in the Extracellular Tumor Microenvironment Using CEST MRI and Other Imaging Methods

Figure 2

Tumor acidosis causes chemoresistance against weak-base drugs. (a) Uptake and retention of mitoxantrone, a weak-base drug, was greater in C3H tumor tissue that was neutralized with sodium bicarbonate. (b) Mitoxantrone treatment (1 dose of 12 mg/kg or 2 doses of 6 mg/kg) caused a greater growth delay when sodium bicarbonate neutralized the tumor acidosis. (c) Sodium bicarbonate also improved survival with mitoxantrone treatment. Reproduced with permission from [10].

(a)

(b)

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