The Genome Sequence of Methanohalophilus mahii SLP^T Reveals Differences in the Energy Metabolism among Members of the Methanosarcinaceae Inhabiting Freshwater and Saline Environments

Figure 5

Proposed pathway of methanogenesis in Mhp. mahii. Numbers in circles indicate involved enzymes: (1), methyltransferase system; (2), methyl-CoM reductase; (3), methyl-H₄MPT:HS-CoM methyltransferase; (4), methylene-H₄MPT reductase; (5), methylene-H₄MPT dehydrogenase; (6), methenyl-H₄MPT cyclohydrolase; (7), formyl-MF:H₄MPT formyltransferase; (8), formyl-MF dehydrogenase; (9), acetyl-CoA synthase/CO dehydrogenase. Abbreviations: Fd_red, reduced ferredoxin; Fd_ox, oxidized ferredoxin; MF, methanofuran; H₄MPT, tetrahydromethanopterin; F₄₂₀H₂, reduced coenzymeF₄₂₀; F₄₂₀, oxidized coenzyme F₄₂₀; CoA-SH, coenzyme A; CoM-SH, coenzyme M; CoB-SH, coenzyme B; CoM-S-S-CoB, heterodisulfide of CoM and CoB.