Improving the Catalytic Activity of Hyperthermophilic Pyrococcus horikoshii Prolidase for Detoxification of Organophosphorus Nerve Agents over a Broad Range of Temperatures

<table>Relative activity with WT-Pfprol and P. horikoshii prolidases with OP nerve agent DFP. All prolidase assays contained 50 mM MOPS, 200 mM NaCl, pH 7.0, 0.2 mM CoCl2, and 3 mM DFP. 100% relative activity corresponds to WT-Pfprol specific activity for DFP of 0.42 μmoles product formed/min/mg at 35°C and 0.73 μmoles product formed/min/mg at 50°C.</table>

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Figure 1: Improving the Catalytic Activity of Hyperthermophilic Pyrococcus horikoshii Prolidase for Detoxification of Organophosphorus Nerve Agents over a Broad Range of Temperatures

Figure 1 | Improving the Catalytic Activity of Hyperthermophilic Pyrococcus horikoshii Prolidase for Detoxification of Organophosphorus Nerve Agents over a Broad Range of Temperatures 