Role of Motif III in Catalysis by Acetyl-CoA Synthetase
Position of motif III residues in the active sites of (a) AcsSc, (b) AcsSe, and (c) the Acs1Mt structural model. Acs1Mt modeled on the AcsSe structure (PDB:2P2F) using Accelrys DS Modeler and the stereo images were created using Accelrys DS ViewerPro 5.0. For clarity in viewing, only some residues within the 10Å sphere of AMP are shown. AMP is shown in blue, and the motif III residues are shown in green. Residues discussed in the text are labeled.
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