Role of Motif III in Catalysis by Acetyl-CoA Synthetase
Inhibition of Acs1Mt. (a) Ribose, (b) adenosine, (c) 2′-deoxyadenosine, and (d) 3′-deoxyadenosine. Assays were performed with the indicated concentrations of inhibitor in the reaction, and results are plotted as a percentage of the activity observed in the absence of inhibitor, with error bars as shown. The value for each inhibitor was determined by extrapolation of the data.
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