Crystal Structure of a 9-Subunit Archaeal Exosome in Pre-Catalytic States of the Phosphorolytic Reaction

Figure 1

Overall structure of the S. solfataricus exosome with the two RNase PH subunits Rrp41 and Rrp42 displayed in blue and green, respectively, and the RNA binding protein Rrp4 displayed in yellow. The bound RNA substrate is shown as a stick model and the inorganic phosphate atoms as spheres. The picture on the right shows a 90-degree rotation around the horizontal axis with the 3-fold symmetry axis indicated as a triangle.